Major diabetes discovery holds promise for new treatments

Researchers in the United States have made a major new discovery in the fight against diabetes, and it may lead them to new treatments for the disease. Diabetes affects millions of people around the world. The disease hampers the body’s ability to produce insulin, which is used to regulate blood sugar levels. Without the needed insulin, sugar levels in the blood become too high, and this can lead to a host of complications, such as heart disease, kidney disease and even loss of limbs. There are a few types of diabetes, but there are two that are most common. Type 1 sufferers have the disease from birth and it causes insulin deficiency. Type 2 is acquired later in life (usually through poor diet) and it causes the body’s cells to not use insulin efficiently, and it can also involve insulin deficiency.
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TXNIP Protein Pathway Discovery Could Point To Possible Diabetes Treatment

Louis, Mo., a diabetes expert not involved with the new study, described the research as a major advance in understanding the origin and progression of diabetes. Urano’s research has revealed that excessive TXNIP is produced as a result of stress on a cell structure called the endoplasmic reticulum (ER). He said the new study points to researchers’ growing understanding that TXNIP is a key player in a host of diseases related to ER stress, such as Alzheimer’s disease, Parkinson’s disease, and Wolfram Syndrome, Urano’s specialty, a rare genetic disorder whose symptoms include type 1 diabetes, blindness and deafness. Health experts say that a diet rich in fiber and complex carbohydrates found in leafy green vegetables, legumes and whole grains can help prevent type 2 diabetes. Once diabetes progresses, however, repairing damaged beta cells remains difficult to impossible.
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Mood disorder drugs may triple kids’ diabetes risk

Cunningham / NEW YORK DAILY NEWS Monday, August 26, 2013, 4:02 PM Sterling Cleveland, 32, just finished walking across America to raise money for diabetes prevention. Cleveland made the seven month journey in honor of his grandmother, who succumbed to the disease. Related Stories Mayor Bloomberg: Obesity is a poor thing, the rich have Pilates A Bronx man has just walked across America in support of diabetes prevention. Sterling Cleveland, 32, spent almost eight months walking from Los Angeles to New York City to highlight the scourge of diabetes, raising more than $25,000 for the American Diabetes Association. RELATED: DOCTORS TO ‘PRESCRIBE’ FRUITS, VEGETABLES TO FIGHT OBESITY One thing you learn on such a voyage: Its a big country. For Cleveland who spent part of his youth in Kingsbridge his journey was personal. The grandmother who raised him died of Type II diabetes when he was 21.
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Bronx man walks the walk for diabetes awareness


Previous studies have linked this drug class and diabetes risk in adults on the medications, but the researchers wanted to see if the same held true in kids. The new study involved more than 29,000 young people between ages 6 and 24 who were prescribed the drugs for attention, behavioral and mood disorders. They were compared to more than 14,400 children who were taking other mental health medications including mood stabilizers (lithium), antidepressants, stimulant medications and benzodiazepines. They were tracked for 12 years. Of all subjects, the researchers found 106 young people were diagnosed with and treated for Type 2 diabetes.
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